 D-arabinitol is the characteristic a metabolite produced by genus Candida which is well known to cause a deepseated mycosis in mammals *1. The serum level of D-arabinitol is known to increase when Candida yeast proliferates in the body of a patient having a invasive candidiasis *2. On the other hand serum level of D-arabinitol decreases when the proliferation of the Candida is suppressed by an antifungal therapy or by restoring of immune system *3. Thus determination of serum level of D-arabinitol could be a good marker for the attenuation of a Candida species in a body.
ARABINITEC-AUTO is a simple assay reagent kit for the automatic measurement of D-arabinitol in serum. This kit utilizes a enzyme system which comprises D-arabinitol dehydrogenase combined with a color development system of diaphorase with WST-1, and enables a rapid and highly sensitive determination of D-arabinitol in a single channel using a self blank method without pretreatment.
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|
| Normal reference value*4-*5 |
: D-arabinitol |
19 μmol / l or less |
| : Creatinine ratio |
1.5 μmol / mg creatinine or less |
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| Name |
Constituent reagent |
Package |
Method of storage |
| ARABINITEC-AUTO |
Reagent 1 Enzyme |
16 ml use x 2 |
Store protected
from light
at 4-8 ºC
|
| Reagent 1 Solvent |
16 ml x 2 |
| Reagent 2 Enzyme |
5 ml use x 2 |
| Reagent 2 Solvent |
5 ml x 2 |
| Standard solution1 |
10 ml x 1 |
| Standard solution2 |
10 ml x 1 |
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|
| *1. |
Okudaira M., Tr. Soc. Pathol. Jpn., 74, 61-91 (1985) |
| *2. |
Soyama K., et al., Clin. Chim. Acta, 149, 149-154 (1985) |
| *3. |
Soyama K., et al., Jpn. J. Med. Mycol., 27, 165-169 (1986) |
| *4. |
Soyama K., et al., Jpn. J. Clin. Pathol.(Japanese), 35, 1039-1042 (1987) |
| *5. |
Hamada K., Clin. Microbiology(Japanese), 17, 314-324 (1990) |
| *6. |
Sasaki T., et al., JJCLA(Japanese), 22, 169-172 (1997) |
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